Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats

B Çetinkaya Demir, Y Uyar, K Özbilgin… - Journal of Obstetrics …, 2013 - Wiley Online Library
Aim: The goal of this study was to investigate the combined effects of raloxifene and
atorvastatin in aged ovariectomized rats during endothelial dysfunction and atherosclerotic …

[HTML][HTML] Comparative effects of estrogen, raloxifene and tamoxifen on endothelial dysfunction, inflammatory markers and oxidative stress in ovariectomized rats

AZ Lamas, IF Caliman, PLM Dalpiaz, AF de Melo Jr… - Life sciences, 2015 - Elsevier
Aim Endothelial dysfunction is considered a premature indication of atherosclerosis and
vessel damage and is present in the postmenopausal period. This study compares the …

Effects of estradiol, cyproterone acetate, tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fed rabbits

A Sanjuan, C Castelo-Branco, M Colodron, C Ascaso… - Maturitas, 2003 - Elsevier
Background: Different hormonal replacement regimens are used for treating climacteric
complaints; however, not all of them have the same clinical profile. Cardiovascular disease …

Repercussions of raloxifen, tamoxifen and estrogen on aortic atherosclerotic lesions of female rabbits submitted to ovariectomy and hypercholesterol diet

CK Hueb, JM Aldrighi, E Kallás, JAF Ramires - Maturitas, 2005 - Elsevier
Background: The role of hormone-replacement therapy in decreasing the risk of
cardiovascular disease in women has not been firmly established. Recent studies have …

A novel concept to preserve the beneficial effects of hormone replacement therapy in bilaterally female ovariectomized rats: role of lovastatin therapy

SE El-Swefy, ME Asker, SI Ali, HE Mohammed - Pharmacological research, 2002 - Elsevier
Estrogen replacement therapy (ERT) is claimed to reduce cardiovascular mortality by about
50% in postmenopausal women. This improvement is caused by favorable changes in lipid …

Raloxifene prevents endothelial dysfunction in aging ovariectomized female rats

CM Wong, X Yao, CL Au, SY Tsang, KP Fung… - Vascular …, 2006 - Elsevier
Lack of an appropriate animal model has delayed the better understanding of mechanisms
related to higher cardiovascular risk in women after menopause. The aging female rat may …

Chronic effects of toremifene on the vasculature of menopause-induced rats

J González-Pérez, MJ Crespo - Vascular pharmacology, 2003 - Elsevier
During menopause, women have a higher propensity for developing cardiovascular
diseases. Recent studies have shown that treatment with selective estrogen receptor …

A comparative study of efficacy of tibolone and simvastatin on atherosclerosis in ovariectomized cholesterol-fed rabbits

Y Cui, D Zhao, H Liu, Z Ning, J Yang, X Qing, S Yu… - Maturitas, 2005 - Elsevier
BACKGROUND:: After menopause women are more susceptible to coronary heart disease
due to increased risk of atherosclerosis. Tibolone (Livial) is an innovative synthetic steroid …

Raloxifene and estrogen reduces progression of advanced atherosclerosis—a study in ovariectomized, cholesterol-fed rabbits

NH Bjarnason, J Haarbo, I Byrjalsen, P Alexandersen… - Atherosclerosis, 2001 - Elsevier
The present study investigated the effect of raloxifene, a selective estrogen receptor
modulator (SERM), on aortic atherosclerosis in 80 ovariectomized, cholesterol-fed rabbits …

Estrogen and progestogen inhibit NF-κB in atherosclerotic tissues of ovariectomized ApoE (−/−) mice

Y Chen, H Zhao, X Ren - Climacteric, 2016 - Taylor & Francis
Objectives: To determine the effects of estrogen and progestogen treatment on
atherosclerotic inflammation and vascular remodeling. Methods: Atherosclerosis was …