Neuroprotective effect and possible mechanisms of berberine in diabetes-related cognitive impairment: A systematic review and meta-analysis of animal studies

Y Hao, J Li, S Yue, S Wang, S Hu, B Li - Frontiers in Pharmacology, 2022 - frontiersin.org
Berberine, the main bioactive component of Coptis chinensis Franch., is widely used in the
treatment of diabetes. Previous studies have reported that berberine supplementation may …

Berberine ameliorates diabetes-associated cognitive decline through modulation of aberrant inflammation response and insulin signaling pathway in DM rats

Q Chen, R Mo, N Wu, X Zou, C Shi, J Gong… - Frontiers in …, 2017 - frontiersin.org
Background: Memory-impairment was one of the common characteristics in patients with
diabetes mellitus. The release of chronic inflammation mediators and insulin resistance in …

Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization in diabetic db/db mice: a magnetic resonance …

X Yang, C Yang, X Wang, L Zhang, Z Shi, D Jiang… - Metabolic Brain …, 2024 - Springer
Diabetic cognitive impairment is a common complication in type 2 diabetes. Berberine (BBR)
is an isoquinoline alkaloid that has been shown to have neuroprotective effects against …

Berberine ameliorates spatial learning memory impairment and modulates cholinergic anti-inflammatory pathway in diabetic rats

K Wang, Q Chen, N Wu, Y Li, R Zhang… - Frontiers in …, 2019 - frontiersin.org
Background: Cognitive impairment caused by diabetes has been recognized. Berberine is
well known for its resistance to peripheral lesions, but it is rarely used for the treatment of …

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

N Shinjyo, J Parkinson, J Bell, T Katsuno… - Journal of integrative …, 2020 - Elsevier
Background A growing number of epidemiological studies indicate that metabolic syndrome
(MetS) and its associated features play a key role in the development of certain …

Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes

L Wu, X Meng, T Xu, X Zhang, Y Zhou… - Chemical Biology & …, 2024 - Wiley Online Library
The cognitive dysfunction caused by prediabetes causes great difficulties in human life, and
the terrible thing is that the means to prevent the occurrence of this disease are very limited …

[HTML][HTML] Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment

Y Zheng, C Wang, W Liu, J Chen, Y Sun… - Biomedicine & …, 2024 - Elsevier
Background and aim Diabetes-associated cognitive impairment (DCI) is a prevalent
complication of diabetes. However, there is a lack of viable strategies for preventing and …

Effects of berberine on diabetes and cognitive impairment in an animal model: the mechanisms of action

JH Zhang, JF Zhang, J Song, Y Bai, L Deng… - The American journal …, 2021 - World Scientific
Diabetes is a group of metabolic disorders with an increased risk of developing cognitive
impairment and dementia. The hippocampus in the forebrain contains an abundance of …

Co-administration of berberine/gypenosides/bifendate ameliorates metabolic disturbance but not memory impairment in type 2 diabetic mice

M Zhang, J Li, X Guo, X Wang, D Shi, L Cui, Y Zhou - Heliyon, 2021 - cell.com
Cognitive impairment is a well-known complication of Type 2 diabetes mellitus (T2DM)
characterized by cellular insulin resistance, chronic inflammation, and metabolic …

Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice

HY Li, XC Wang, YM Xu, NC Luo, S Luo… - Rejuvenation …, 2018 - liebertpub.com
The association between diabetes and dementia has been well demonstrated by
epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and …