The recent development of molecular biology and mouse genetics and the analysis of the
skeletal phenotype induced by genetic mutations in humans led to a better understanding of …

Abstract Runx2, osterix, and β‐catenin are essential for osteoblast differentiation. Runx2
directs multipotent mesenchymal cells to an osteoblastic lineage, and inhibits them from …

Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells.
Here, we discuss transcription factors that are involved in regulating the multistep molecular …

Formation of skeletal elements during embryogenesis and the dynamic remodeling of bone
in the adult involve an exquisite interplay of developmental cues, signaling proteins …

The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation
and bone formation. Runx2 expression occurs at early stages of osteochondroprogenitor …

Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Abstract The Cbfa1/Runx2 is an important transcription factor necessary for osteoblast
differentiation and bone formation. However, the signaling pathways regulating Runx2 …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

We present an overview of the concepts of tissue-specific transcriptional control
mechanisms essential for development of the bone cell phenotype. BMP2 induced …

The differentiation of osteoblasts from mesenchymal precursors requires a series of cell fate
decisions controlled by a hierarchy of transcription factors. Among these are RUNX2, Osterix …