The Hedgehog signaling pathway regulates embryo patterning and progenitor cell
homeostasis in adult tissues, including epidermal appendages. A role for the Hh pathway in …

The Hedgehog pathway is vital for the development of many epidermal appendages, but its
role in mammary development has been unclear. Here, we show that although Gli2 and Gli3 …

Abstract The Hedgehog (Hh) signaling pathway functions as an organizer in embryonic
development. Genetic analysis has demonstrated a critical role for the Hh pathway in …

The Hedgehog pathway is critical for many developmental processes, including the
formation of several epidermal appendages. In the mammary gland strict regulation of the …

Sonic Hedgehog (Shh) is a secreted morphogen that directs patterning and cellular
differentiation through binding to its receptor Patched (Ptc). It is required for the development …

The Hedgehog (Hh) signaling pathway, which is well conserved even in mammals and other
vertebrate species, has long been known to direct growth and patterning during embryonic …

The Hedgehog signaling network regulates organogenesis, cell fate, proliferation, survival,
and stem cell self-renewal in many mammalian tissues. Aberrant activation of the Hedgehog …

Despite much progress toward understanding how epithelial morphogenesis is shaped by
intra-epithelial processes including contractility, polarity, and adhesion, much less is known …

The hedgehog signal transduction network is a critical mediator of cell-cell communication
during embryonic development. Evidence also suggests that properly regulated hedgehog …

The Hedgehog signaling pathway regulates the development and function of numerous
tissues and when mis-regulated causes tumorigenesis. To assess the role of a deregulated …