Ca2+- and Metabolism-Related Changes of Mitochondrial Potential in Voltage-Clamped CA1 Pyramidal Neurons In Situ

S Schuchmann, M Luckermann… - Journal of …, 2000 - journals.physiology.org
In hippocampal slices from rats, dialysis with rhodamine-123 (Rh-123) and/or fura-2 via the
patch electrode allowed monitoring of mitochondrial potential (ΔΨ) changes and …

Mitochondria buffer Ca2+ entry but not intracellular Ca2+ release in mouse DRG neurones

N Svichar, P Kostyuk, A Verkhratsky - Neuroreport, 1997 - journals.lww.com
MITOCHONDRIAL Ca 2+ pool was investigated in dorsal root ganglion neurones acutely
isolated from 4–5 week old mice. Under the resting conditions application of mitochondrial …

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

MR Duchen - Biochemical Journal, 1992 - portlandpress.com
Depolarization of neurons promotes Ca2+ influx through voltage-activated channels, raising
the intracellular Ca2+ concentration ([Ca2+] i). The consequences of such changes in …

Changes in [Ca2+]i and membrane currents during impaired mitochondrial metabolism in dissociated rat hippocampal neurons

AV Nowicky, MR Duchen - The Journal of Physiology, 1998 - Wiley Online Library
1 This study was designed to establish the basis for altered membrane excitability during the
inhibition of mitochondrial metabolism in central mammalian neurons. Perforated whole‐cell …

A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ Homeostasis

SL Budd, DG Nicholls - Journal of neurochemistry, 1996 - Wiley Online Library
The ability of mitochondrial Ca2+ transport to limit the elevation in free cytoplasmic Ca2+
concentration in neurones following an imposed Ca2+ load is reexamined. Cultured …

Depolarization-induced mitochondrial Ca accumulation in sympathetic neurons: spatial and temporal characteristics

NB Pivovarova, J Hongpaisan… - Journal of …, 1999 - Soc Neuroscience
Several lines of evidence suggest that neuronal mitochondria accumulate calcium when the
cytosolic free Ca2+ concentration ([Ca2+] i) is elevated to levels approaching∼ 500 nm, but …

Imaging mitochondrial calcium dynamics in the central nervous system

R Serrat, A Oliveira-Pinto, G Marsicano… - Journal of Neuroscience …, 2022 - Elsevier
Mitochondrial calcium handling is a particularly active research area in the neuroscience
field, as it plays key roles in the regulation of several functions of the central nervous system …

Mitochondrial Ca2+ signalling in hippocampal neurons

KW Young, ETW Bampton, L Pinòn, D Bano, P Nicotera - Cell calcium, 2008 - Elsevier
High-resolution fluorescent imaging of mitochondrial-targeted probes was used to examine
the ability of mitochondria to decode complex spatial and temporal Ca2+ signals evoked in …

Mitochondrial participation in the modulation of calcium transients in DRG neurons

N Svichar, V Shishkin, P Kostyuk - Neuroreport, 1999 - journals.lww.com
THE effects of the mitochondrial Na+/Ca 2+ exchange blocker tetraphenylphosphonium
(TPP+) and the permeability transition blocker cyclosporinA (CysA) on the ability of …

Frequency-and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

O Stoler, A Stavsky, Y Khrapunsky, I Melamed… - Elife, 2022 - elifesciences.org
Mitochondrial activity is crucial for the plasticity of central synapses, but how the firing pattern
of pre-and postsynaptic neurons affects the mitochondria remains elusive. We recorded …