Background: Male infertility is a multifactorial disorder, which affects approximately 10% of
couples at childbearing age with substantial clinical and social impact. Genetic factors are …

Male infertility is a complex multifactorial disease affecting approximately 10% of couples
who want to have children. Some cases of infertility can be explained by genetic factors …

SEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells.
SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental …

Background: Septins are an evolutionary conserved group of GTP-binding and filament-
forming proteins that have diverse cellular roles. An increasing body of data implicates the …

It is estimated that 10–15% of couples are infertile and male factors account for about half of
these cases. With the advent of intracytoplasmic sperm injection (ICSI), many infertile men …

An increasing body of data implicates the Septin family in the pathology of several diseases,
including male fertility. The objective of this study was to evaluate the gene and protein …

Background and aims Motility and morphological defects of spermatozoa can cause male
infertility. Sperm RNAs are related to sperm quality. They are considered to have clinical …

Genetic mechanisms have been implicated as a cause of some cases of male infertility.
Recently, 10 novel genes involved in human spermatogenesis, including human SEPTIN12 …

Purpose To investigate the expression pattern of the SEPT7 protein during spermatogenesis
and its potential role in sperm function. Methods We first investigated the expression pattern …

Purpose To investigate the association between SEPTIN12 gene variants and the risk of
azoospermia caused by meiotic arrest. Methods Mutational analysis of the SEPTIN12 gene …