G protein-coupled receptors disrupted in human genetic disease
MD Thompson, ME Percy, WMI Burnham… - … in Drug Discovery and …, 2008 - Springer
Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR
function in a wide variety of human genetic diseases. In vitro strategies have been used to …
function in a wide variety of human genetic diseases. In vitro strategies have been used to …
G protein-coupled receptor mutations and human genetic disease
MD Thompson, GN Hendy, ME Percy… - … in drug discovery and …, 2014 - Springer
Genetic variations in G protein-coupled receptor genes (GPCRs) disrupt GPCR function in a
wide variety of human genetic diseases. In vitro strategies and animal models have been …
wide variety of human genetic diseases. In vitro strategies and animal models have been …
Genetic variations in human G protein-coupled receptors: implications for drug therapy
Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for
drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR …
drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR …
Molecular Manipulation of G Protein coupled Receptors A New Avenue into Drug Discovery
M Sautel, G Milligan - Current medicinal chemistry, 2000 - ingentaconnect.com
During the past 10 years or so, associated with the introduction of molecular biology
techniques to G protein coupled receptor (GPCR) research, outstanding progress has been …
techniques to G protein coupled receptor (GPCR) research, outstanding progress has been …
Genetic variation in G-protein-coupled receptors–consequences for G-protein-coupled receptors as drug targets
CM Tang, PA Insel - Expert opinion on therapeutic targets, 2005 - Taylor & Francis
G-protein-coupled receptors (GPCRs), including 'orphan'GPCRs whose natural ligands are
unknown, comprise the largest membrane receptor superfamily and are the most commonly …
unknown, comprise the largest membrane receptor superfamily and are the most commonly …
Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications
BK Rana, T Shiina, PA Insel - Annual review of pharmacology …, 2001 - annualreviews.org
G protein-coupled receptors (GPCRs) represent a major class of proteins in the genome of
many species, including humans. In addition to the mapping of a number of human …
many species, including humans. In addition to the mapping of a number of human …
Pharmacogenetics of the G protein-coupled receptors
Pharmacogenetics investigates the influence of genetic variants on physiological
phenotypes related to drug response and disease, while pharmacogenomics takes a …
phenotypes related to drug response and disease, while pharmacogenomics takes a …
G protein-coupled receptor pharmacogenetics
MD Thompson, KA Siminovitch, DEC Cole - Pharmacogenomics in Drug …, 2008 - Springer
Common G protein-coupled receptor (GPCR) gene variants that encode receptor proteins
with a distinct sequence may alter drug efficacy without always resulting in a disease …
with a distinct sequence may alter drug efficacy without always resulting in a disease …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
T Schöneberg, I Liebscher - Pharmacological reviews, 2021 - ASPET
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily
KM Small, DA Tanguay, K Nandabalan, P Zhan… - American Journal of …, 2003 - Springer
Introduction: Guanine nucleotide binding proteins (G-proteins) represent the targets for>
50% of all therapeutics. There is substantial interindividual variation in response to agonists …
50% of all therapeutics. There is substantial interindividual variation in response to agonists …