[HTML][HTML] Signaling triggered by Thy-1 interaction with ß3 integrin on astrocytes is an essential step towards unraveling neuronal Thy-1 function

ANA AVALOS, CV Labra, AFG Quest, L Leyton - Biological Research, 2002 - SciELO Chile
Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such prevalence, Thy-1
function remains largely obscure in the absence of a defined ligand. Recently described …

Thy-1 binds to integrin β3 on astrocytes and triggers formation of focal contact sites

L Leyton, P Schneider, CV Labra, C Rüegg, CA Hetz… - Current Biology, 2001 - cell.com
Background: Thy-1 is an abundant neuronal glycoprotein in mammals. Despite such
prevalence, Thy-1 function remains largely obscure in the absence of a defined ligand …

[HTML][HTML] Direct Thy-1/αVβ3 integrin interaction mediates neuron to astrocyte communication

T Hermosilla, D Muñoz, R Herrera-Molina… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Thy-1 is an abundant neuronal glycoprotein of poorly defined function. We recently provided
evidence indicating that Thy-1 clusters a β3-containing integrin in astrocytes to induce …

Thy-1-interacting molecules and cellular signaling in cis and trans

R Herrera-Molina, A Valdivia, M Kong, A Alvarez… - International review of …, 2013 - Elsevier
Abstract Thy-1, discovered almost 50 years ago, was for many years a subject of great
scientific interest. The putative functions attributed to this molecule could not be confirmed …

[HTML][HTML] Getting a grip on Thy-1 signaling

TH Barker, JS Hagood - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
A recent study by Hermosilla et al.[T. Hermosilla, D. Munoz, R. Herrera-Molina, A. Valdivia,
N. Munoz, SU Nham, P. Schneider, K. Burridge, AF Quest, L. Leyton, Direct Thy …

Thy-1 modulates neurological cell–cell and cell–matrix interactions through multiple molecular interactions

L Leyton, JS Hagood - Cell Adhesion Molecules: Implications in …, 2013 - Springer
Abstract Thy-1, or CD90, is a glycosylphosphatidylinositol-linked cell surface glycoprotein
expressed on multiple cell types, including neurons, thymocytes, fibroblasts, endothelial …

[HTML][HTML] Thy-1-mediated cell–cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4

M Kong, N Muñoz, A Valdivia, A Alvarez… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Cell adhesion to the extracellular matrix proteins occurs through interactions with integrins
that bind to Arg-Gly-Asp (RGD) tripeptides, and syndecan-4, which recognizes the heparin …

Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes

AM Avalos, WT Arthur, P Schneider, AFG Quest… - Journal of Biological …, 2004 - ASBMB
Thy-1, a cell adhesion molecule abundantly expressed in mammalian neurons, binds to a β
3-containing integrin on astrocytes and thereby stimulates the assembly of focal adhesions …

Astrocytic αVβ3 Integrin Inhibits Neurite Outgrowth and Promotes Retraction of Neuronal Processes by Clustering Thy-1

R Herrera-Molina, R Frischknecht, H Maldonado… - PLoS …, 2012 - journals.plos.org
Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal
processes. However, its precise function has remained obscure, because its endogenous …

Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA

AM Avalos, AD Valdivia, N Muñoz… - Journal of cell …, 2009 - journals.biologists.com
Clustering of αvβ3 integrin after interaction with the RGD-like integrin-binding sequence
present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in …