Gonadotropin-releasing hormone (GnRH) induces both synthesis and release of pituitary
gonadotropins, but rapid or slow frequencies of stimulation result in reduced LH and FSH …

To determine whether pituitary gonadotroph desensitization is a consequence of loss of
gonadotropin-releasing hormone (GnRH) receptors (GnRH-R), these were analyzed in …

The hypothalamic hormone, GnRH, is released and transported to the anterior pituitary in a
pulsatile manner, where it binds to specific high-affinity receptors and regulates …

To further evaluate the role of GnRH in the regulation of pituitary gonadotropin-releasing
hormone receptors (GnRH-R) in male rats in vivo, endogenous GnRH was neutralized with …

The effects of increasing the frequency of pulsatile GnRH administration on LH and FSH
responsiveness were studied in five GnRH-deficient men who had achieved normal sex …

The relationship between pituitary GnRH receptors (GnRH-R) and LH responsiveness to
GnRH stimulation is not straightforward. In some circumstances, eg post-gonadectomy of …

We recently demonstrated that chronic daily administration of a superactive GnRH analog to
intact rats resulted in an initial stimulation of serum LH levels with a subsequent return of LH …

Recent evidence indicates that endogenous GnRH is required for maintenance of its own
pituitary receptors (GnRH-R). We have measured GnRH-R in pituitaries of …

The regulatory role of pituitary gonadotropinreleasing hormone (GnRH) receptors in the
control of gonadotropin secretion was investigated in male and female rats after castration …

Recent studies in male rats have shown that the number of pituitary gonadotropin-releasing
hormone (GnRH) receptors is increased by castration and by injections of GnRH. This …