Unlike other Salmonellae, the intracellular bacterial human pathogen Salmonella Typhi
exhibits strict host specificity. The molecular bases for this restriction are unknown. Here we …

Unlike broad-host Salmonella serovars, which cause self-limiting disease, Salmonella
enterica serovar Typhi can infect only humans causing typhoid fever, a life-threatening …

Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-
bound vacuoles through the action of effector proteins translocated into host cells …

Cell-autonomous defense mechanisms are potent strategies that protect individual cells
against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to …

Several intracellular pathogens have developed diverse strategies to avoid targeting to
lysosomes. However, they universally recruit lysosome-associated membrane protein 1 …

The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense
mechanism that restricts the replication of intravacuolar pathogens such as Salmonella …

Salmonella Typhimurium is an intracellular pathogen that causes gastroenteritis in humans.
Aided by a battery of effector proteins, S. Typhimurium resides intracellularly in a specialized …

The food-borne bacterial pathogen Salmonella Typhimurium uses a type III protein secretion
system to deliver multiple proteins into host cells. These secreted effectors modulate the …

A type III protein secretion system encoded by Salmonella pathogenicity island 2 (SPI2) has
been found to be required for virulence and survival within macrophages. Here, SPI2 was …

Intracellular pathogens such as Salmonella depend on their molecular virulence factors to
evade host defense responses like autophagy. Using a zebrafish systemic infection model …