Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes

S Casas‐Grajales, LF Vázquez‐Flores… - Fundamental & …, 2017 - Wiley Online Library
The ability of quercetin to reverse an established cirrhosis has not yet been investigated.
Therefore, the aim of this study was to examine the efficacy of this flavonoid in reversing …

Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis

A Pavanato, MJ Tuñón, S Sánchez-Campos… - Digestive diseases and …, 2003 - Springer
Flavonoids are reported to exhibit a wide variety of biological effects, including antioxidant
and free radical-scavenging activities. Evidence of oxidative reactions is often associated …

Quercetin prevents oxidative stress in cirrhotic rats

PM Amália, MN Possa, MC Augusto… - Digestive diseases and …, 2007 - Springer
Our aim was to study the protective effect of quercitin on liver cirrhosis induced by carbon
tetrachloride (CCl 4) in rats and its relationship with liver morphology. Thirty male Wistar rats …

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

Y Wan, MH Tang, XC Chen, LJ Chen… - Brazilian Journal of …, 2014 - SciELO Brasil
Immune response plays an important role in the development of hepatic fibrosis. In the
present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis …

The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

ES Lee, HE Lee, JY Shin, S Yoon… - Journal of pharmacy …, 2003 - Wiley Online Library
Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

R Wang, H Zhang, Y Wang, F Song, Y Yuan - International …, 2017 - Elsevier
Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …

Effect of antioxidant treatment on fibrogenesis in rats with carbon tetrachloride‐induced cirrhosis

S Bona, LI Filippin, FC Di Naso… - International …, 2012 - Wiley Online Library
Aim. This study aimed to assess the antioxidant activity of quercetin (Q) in an experimental
model of cirrhosis induced by CCl4 inhalation. Materials and Methods. We used 25 male …

The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta‐analysis

X Guo, Y Li, W Wang, L Wang, S Hu… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Quercetin (3, 3′, 4′, 5, 7‐pentahydroxyflavone), a flavonoid, is widely found in
fruits and vegetables and exerts broad‐spectrum pharmacological effects in the liver. Many …

Antioxidant, antiinflammatory, and antifibrotic properties of quercetin in the liver

LF Vázquez-Flores, S Casas-Grajales… - Liver …, 2017 - Elsevier
Quercetin (Q) is a ubiquitous flavonoid founded in several natural sources, mainly in skin
apples and red onions. Q possesses potent antioxidant properties, as well as metal …