Bacterial infection occasionally has a marked therapeutic effect on malignancies, as noted
as early as the 19th century. Recently, there have been attempts to develop cancer …

We report here a modified auxotrophic strain of Salmonella typhimurium that can target and
cure breast tumors in orthotopic mouse models. We have previously reported development …

Here we report a genetically modified bacteria strain, Salmonella typhimurium A1, selected
for anticancer activity in vivo. The strain grows in tumor xenografts. In sharp contrast, normal …

We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic
strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires …

Cancer of the exocrine pancreas is the fourth leading cause of cancer deaths in the United
States. Currently, surgical resection is the only hope for cure. The majority of patients …

Cancer metastasis is the life‐threatening aspect of cancer and is usually resistant to
standard treatment. We report here a targeted therapy strategy for cancer metastasis using a …

We report here the efficacy of tumor‐targeting Salmonella typhimurium A1‐R (A1‐R) on
mouse models of disseminated and metastatic ovarian cancer. The proliferation‐inhibitory …

We report here a new targeting strategy for primary bone tumor and lung metastasis with a
modified auxotrophic strain of Salmonella typhimurium. We have previously developed the …

We have developed the genetically-modified Salmonella typhimurium A1-R strain that
selectively targets tumors. S. typhimurium A1-R is auxotrophic for Leu and Arg, which …

In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent
cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella …