This study was designed to investigate the prophylactic effects and the mechanisms of
curcumin on liver fibrosis in rats. Liver fibrosis was induced in 72 Sprague Dawley rats by …

Suppression of activation or fibrogenesis and induction of apoptosis, in hepatic stellate cells
(HSCs) have been proposed as therapeutic strategies against liver fibrosis. Curcumin, an …

Abstract Background and Aim: Curcumin, the major polyphenolic compound in turmeric, has
been shown to attenuate hepatic damage in several animal models of liver injury. The aim of …

Inflammation and hepatic stellate cell (HSC) activation are the most crucial steps in the
formation of hepatic fibrosis. Hepatocytes damaged by viral or bacterial infection, alcohol or …

Background: Liver fibrogenesis can lead to the development of cirrhosis and hepatocellular
carcinoma. This study was designed to evaluate the hepatoprotective effect of curcumin on …

We previously demonstrated that curcumin, a well-known antioxidant, inhibits collagen
deposition in carbon tetrachloride-induced liver injury in rats. The major effector cells …

Curcumin has been reported to have anti-fibrotic effect. However, the anti-fibrotic
mechanism of curcumin for liver fibrosis remains obscure. In the presenting study, we aimed …

The hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis have
rarely been discussed and its mechanisms of action in alcohol-induced liver disease remain …

The present study aimed to assess the hepatocellular protective activity of the co-
administration of curcumin fortified by ginger against carbon tetrachloride (CCl4)-induced …

The CXC motif chemokine 12/CXC chemokine receptor type 4 (CXCL12/CXCR4) biological
axis plays an important role in the pathogenesis of liver fibrosis. Curcumin is known to have …