" If the degenerations, if the senile alterations are disease, a day will come when it is
possible to cure them.... the question is certainly not whether the injections [of aqueous …

This decline is associated with a decrease in libido, muscle mass and strength, leptin levels,
bone mineral density (BMD), hematocrit, and cognition (3–6). It also has been recognized …

T is now well accepted that serum testosterone (T) levels decline progressively with aging in
men (1–5). This decline is associated with alterations in body composition; diminished …

The term frailty describes an age‐related state of vulnerable health. The aetiology of this
condition is not well understood. A number of mechanisms may contribute to frailty. Amongst …

Scientists have been interested in sex hormones and their role in the aging male since the
19th century, when Brown-Sequard, the famous French physiologist, described his …

Although estrogen replacement therapy has become well established in the management of
postmenopausal women, most physicians pay much less attention to the testosterone status …

In contrast to women, men do not experience a sudden cessation of gonadal function
comparable to menopause. However, there is a progressive reduction in male hypothalamic …

Publisher Summary This chapter discusses gonadotropins and plasma testosterone in
senescence. An investigation described in the chapter showed that the testis was capable of …

Background That there is an age-associated decrease in serum-testosterone concentrations
in healthy adult men has only been generally accepted within the past decade, which may …

The recent increase in the elderly population, current health trends, and awareness of age-
related changes in the male endocrine system have led to discussions about the endocrine …