Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca2+ Current in Rat Ventricular Cardiomyocytes

D Michel, JW Wegener, H Nawrath - Pharmacology, 2002 - karger.com
The effects of the enantiomers quinine and quinidine on the transient outward current (Ito)
and on the L-type Ca2+ current (ICa) were investigated in rat ventricular cardiomyocytes …

Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes

K Komeichi, N Tohse, H Nakaya, M Shimizu… - European journal of …, 1990 - Elsevier
The effects of N-acetylprocainamide (NAPA) and sotalol on membrane current systems of
guinea-pig ventricular myocytes were examined and compared with those of quinidine using …

Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane

JW Wegener, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1996 - Springer
The effects of the phenylalkylamines verapamil (V), gallopamil (G), and devapamil (D) and
their corresponding quaternary derivatives on the transient outward current (I to) were …

Effects of cibenzoline, a new class Ia antiarrhythmic drug, on various membrane ionic currents and action potentials of guinea-pig ventricular cells

T Sato, B Wu, T Kiyosue, M Arita - Naunyn-Schmiedeberg's archives of …, 1994 - Springer
We examined the effects of cibenzoline, a new class Ia antiarrhythmic drug, on various
membrane ionic currents and action potentials of guinea-pig single ventricular cells, using …

Mechanism of block by 4-aminopyridine of the transient outward current in rat ventricular cardiomyocytes

JW Wegener, A Peiter, SR Sampson… - Journal of …, 1998 - journals.lww.com
Abstract The effects of 4-aminopyridine (4-AP) on the transient outward current (I to) were
investigated in rat ventricular cardiomyocytes at different values of intracellular pH (pH i) and …

Effects of chloride ion substitutes and chloride channel blockers on the transient outward current in rat ventricular myocytes

T Lefevre, IA Lefevre, A Coulombe… - Biochimica et Biophysica …, 1996 - Elsevier
The Cai2-insensitive transient outward current, ilo was studied at 20–24° C in rat ventricular
myocytes with the whole cell recording patch-clamp technique. The current was recorded …

Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes

U Jahnel, P Klemm, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1994 - Springer
The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes

JW Wegener, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1995 - Springer
The effects of the phenylalkylamines verapamil, gallopamil, and devapamil on L-type
calcium currents (I Ca) were studied in ventricular myocytes from rat hearts using the whole …

Effects of quinidine on plateau currents of guinea-pig ventricular myocytes

M Hiraoka, K Sawada, S Kawano - Journal of molecular and cellular …, 1986 - Elsevier
Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

Quinidine‐induced open channel block of K+ current in rat ventricle

RB Clark, J Sanchez‐Chapula… - British journal of …, 1995 - Wiley Online Library
1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …