Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin
generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic …

Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

There is evidence of activation of both blood coagulation and platelets in sickle cell disease.
For example, plasma samples obtained in the steady state and during painful crisis …

Essentials• Sickle cell disease is increasingly being recognized as a chronic
hypercoagulable state.• Thrombin generation is elevated in the whole blood, but not the …

Sickle cell disease (SCD) is a hematologic disorder caused by a well‐characterized point
mutation in the β‐globin gene. Abnormal polymerization of hemoglobin tetramers results in …

VTE is an underappreciated and potentially morbid complication of SCD. The mechanisms
underlying this hypercoagulable state are complex. A greater understanding of these …

Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting
millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and …

Background The contribution of hypercoagulability to the pathophysiology of sickle cell
disease (SCD) remains poorly defined. We sought to evaluate the association of markers of …

Complex pertubations of hemostasis occur in sickle cell disease (SCD). Although the
procoagulant property of sickle erythrocytes in vitro is tied to exposure of phosphatidylserine …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …