The actions of ambasilide (LU-47110) on the action potential and membrane currents of
isolated guinea pig ventricular myocytes were studied using voltage clamp techniques …

We examined the underlying mechanism for rate-dependent effects of sematilide on action
potential duration (APD) in guinea pig ventricular myocytes. Sematilide at 10 microM or …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

A voltage-clamp analysis of the effect of almokalant on the delayed rectifier K+ current (IK)
was made in rabbit ventricular myocytes. The two-suction pipette method was used, and …

The mechanism of drug-induced inhibition of the transient outward current, I to, has been
investigated in rat ventricular myocytes using the whole cell patch clamp technique. I to was …

The effects of N-acetylprocainamide (NAPA) and sotalol on membrane current systems of
guinea-pig ventricular myocytes were examined and compared with those of quinidine using …

The electrophysiologic effects of ambasilide, a new class III antiarrhythmic drug reported to
be a nonselective blocker of both components (I Kr and I Ks) of the delayed-rectifier …

Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

Objectives The effects of almokalant (4-[3-ethyl [3-(propylsulphinyl) propyl]-amino]-2-hydroxy-
propoxyj-benzonitrile), E-4031 (1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4-methylsulphonyl-amino …

The putative Class III antiarrhythmic benzopyran compound terikalant (RP62719) has been
applied to isolated rat ventricular myocytes. The drug, at extracellular concentrations from 1 …