The underlying causes of most mood and anxiety disorders remain unknown. There is a
strong heritable component to psychiatric illnesses that, when coupled with environmental …

The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Depression is a common and devastating neuropsychiatric disorder, and a better
understanding of its pathophysiology is needed to improve diagnosis, treatment and …

Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …

Depression is a major cause of disability worldwide, but we know little about the underlying
fundamental biology. Research is hindered by the difficulties of modelling a disorder of …

Stress-related mood disorders, including anxiety and depression, have become pervasive in
our world today. Depressive disorders currently affect over 10% of the American population …

A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …