Abstract The Aurora (Ipl1)-related kinases are universal regulators of mitosis. We now show
that Aurora-A, in addition to Aurora-B, regulates kinetochore function in human cells. A two …

Aurora B is a mitotic protein kinase that phosphorylates histone H3, behaves as a
chromosomal passenger protein, and functions in cytokinesis. We investigated a role for …

Opposing roles of Aurora kinases and protein phosphatase 1 (PP1) during mitosis have long
been suggested. Here, we demonstrate that Aurora kinases A and B phosphorylate a …

Precise regulation of kinetochore–microtubule attachments is essential for successful
chromosome segregation. Central to this regulation is Aurora B kinase, which …

Mitotic kinases regulate cell division and its checkpoints, errors of which can lead to
aneuploidy or genetic instability. One of these is Aurora-B, a key kinase that is required for …

A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of
mitotic events. The human Aurora paralogues Aurora-A, Aurora-B, and Aurora-C have a …

Aurora B kinase has a critical role in regulating attachments between kinetochores and
spindle microtubules during mitosis. Early in mitosis, kinase activity at kinetochores is high to …

How the events of mitosis are coordinated is not well understood. Intriguing mitotic
regulators include the chromosomal passenger proteins. Loss of either of the passengers …

Aurora-A, a member of the Aurora/Ipl1-related kinase family, is overexpressed in various
types of cancer and considered to play critical roles in tumorigenesis. To better understand …

The outer kinetochore binds microtubules to control chromosome movement. Outer
kinetochore assembly is restricted to mitosis, whereas the inner kinetochore remains …