Baltimore, MD, USA, 4Dept of Biochemistry and Molecular & Cellular Biology, Georgetown
University, Washington, DC, USA. Collagen alignment, also known as tumor associated …

Stromal collagen alignment has been shown to have clinical significance in a variety of
cancers and in other diseases accompanied by fibrosis. While much of the biological and …

Introduction Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide.
The search for new biomarkers that predict the outcome of HCC patients is ongoing. We …

Liver fibrosis is assessed mainly by conventional staining or second harmonic generation
(SHG) microscopy, which can only provide collagen content in fibrotic area. We propose to …

Liver fibrosis is assessed mainly by conventional staining or second harmonic generation
(SHG) microscopy, which can only provide collagen content in fibrotic area. We propose to …

Second harmonic generation microscopy was performed on both normal and diseased
breast tissue. Differences in the collagen fibre shape between normal, benign and malignant …

BACKGROUND Determining the extent of liver fibrosis has clinically been difficult due to the
lack of a simple, objective method that can accurately quantify the amount of collagen in the …

Extracellular matrix (ECM) has important functions in cell proliferation, differentiation, and
migration, which influence the development and progression of cancer. ECM in tumor …

Extracellular matrix (ECM) remodeling is a critical step of many biological and pathological
processes. However, most of the studies to date lack a quantitative method to measure ECM …

Most tumours have a dense extracellular matrix that inhibits drug diffusion and serves as a
barrier to drug delivery. One of the key components of this barrier is a dense collagen …