Isolated rat CNS mitochondria and cultured cortical astrocytes were examined for behavior
indicative of a mitochondrial permeability transition (mPT). Exposure of isolated CNS …

Calcium overload of neural cell mitochondria plays a key role in excitotoxic and ischemic
brain injury. This study tested the hypothesis that brain mitochondria consist of …

The objective of the present study was to determine the biochemical characteristics of Ca2+-
induced mitochondrial swelling (mitochondrial permeability transition; mPT) and cytochrome …

Mitochondrial permeability transition (PT) is a non‐selective inner membrane
permeabilization, typically promoted by the accumulation of excessive quantities of Ca2+ …

The objective of the present study was to assess the capacity of nonsynaptic brain
mitochondria to accumulate Ca2+ when subjected to repeated Ca2+ loads, and to explore …

Mitochondria were simultaneously isolated from striatum and cortex of adult rats and
compared in functional assays for their sensitivity to calcium activation of the permeability …

The mitochondrial permeability transition (mPT) has been implicated in both excitotoxic and
apoptotic neuronal cell death, despite the fact that it has not been previously identified in …

Mitochondria from different regions of the brain were prepared, and the activation of the
mitochondrial permeability transition (MPT) by calcium was investigated by monitoring the …

The mitochondrial permeability transition (mPT) is increasingly implicated in neuronal cell
death. In the present study, isolated respiring brain mitochondria were examined for their …

Abstract Changes in mitochondrial integrity, reactive oxygen species release and Ca2+
handling are proposed to be involved in the pathogenesis of many neurological disorders …