Human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS)
is a disease pertained to the human immune system. Given its crucial role in viral replication …

Flexible molecular docking is a computational method of structure-based drug design. This
method is used to evaluate binding interactions between receptor and ligand and identify …

We have investigated and highlighted the behavior of binding residue, Asp25 by
computational analysis, which play an important role in understanding docking process with …

Designing and employing enzyme inhibitors against viral enzymes is one of the innovative
and efficient approaches to treating viral diseases. These inhibitors can disrupt the viral …

HIV infected patients often take at least three anti-HIV drugs together in Highly Active
Antiretroviral Therapy (HAART) and/or Ritonavir-Boosted Protease Inhibitor Therapy (PI/r) to …

The current strategy to improve the quality of life of Human Immunodeficiency Virus (HIV)
infected individuals through suppressing viral replication and maintaining the virus at low to …

ABSTRACT HIV-1 protease (PR) is thought to be efficient targets of anti-AIDS drug design.
Molecular dynamics (MD) simulations and multiple post-processing analysis technologies …

HIV-1 protease (PR) is considered to be the main targets of anti-AIDS drug design because
of its role in the proteolytic processing of viral polyproteins. However, the emergence of drug …

The HIV protease enzyme (maturation enzyme) is one of the most promising therapeutic
targets for the treatment of AIDS. Due to the mutation in the virus, there is always room for …

The V82F/I84V double mutation is considered as the key residue mutation of the HIV-1
protease drug resistance because it can significantly lower the binding affinity of protease …