Plasma concentrations are often of major consideration in the evaluation of therapeutic
efficacy of cardiovascular drugs. This approach is based on the assumptions that the …

Oral amiodarone is a potent antiarrhythmic agent with a slow onset of action. Its
electrophysiologic properties following chronic administration are well known, but its acute …

Electrophysiologic effects of the N-desethyl metabolite of amiodarone have been postulated
to explain differences between the effects of acute and chronic amiodarone administration …

It has been suggested that some of the effects of long-term amiodarone therapy may be due
to accumulation of a metabolite, desethylamiodarone. To evaluate the pharmacologic …

The electrophysiologic (EP) effects of chronically administered amiodarone (AM) is known,
but the nature of its acute effects are unclear. Whether the delayed onset of AM action is due …

In 65 patients a single oral dose of amiodarone (30 mg/kg) produced an antiarrhythmic effect
on supraventricular or ventricular arrhythmias within 3 to 8 hours and lasted for 17 to 19 …

The serum kinetics of amiodarone and its major metabolite the deethyl analogue were
studied in rabbits after intravenous administration. The elimination of the drug and the …

During acute superfusion studies by means of the standard microelectrode technique, we
previously showed that both amiodarone and its major metabolite, desethylamiodarone, had …

Antiarrhythmic activity of amiodarone's desethyl metabolite, which accumulates during oral
amiodarone therapy, has been postulated to explain the delayed onset of antiarrhythmic …

We studied the electrophysiological effects of amiodarone on isolated rabbit heart muscles
by conventional microelectrode techniques. It significantly suppressed not only sinus node …