Innate defense regulator-1002 (IDR-1002) is a synthetic peptide with promising
immunomodulatory and antibiofilm properties. An appreciable body of work exists around its …

Innate defense regulators (IDRs) are synthetic host-defense peptides (HDPs) with broad-
spectrum anti-infective properties, including immunomodulatory, anti-biofilm and direct …

Host-defense peptides have drawn significant attention as new drugs or drug adjuvants to
combat multidrug-resistant bacteria. In this study, we report the development of cyclic …

Abstract Innate Defense Regulators (IDRs) are short synthetic peptides that target the host
innate immune system via an intracellular adaptor protein which functions at key signaling …

Host defense (antimicrobial) peptides, produced by all complex organisms, typically contain
an abundance of positively charged and hydrophobic amino acid residues. A small synthetic …

Synthetic peptides derived from naturally occurring host defence peptides (HDPs) have
garnered significant attention as novel pharmaceuticals, particularly as alternatives to …

The multifunctional properties of host defense peptides (HDPs) make them promising drug
candidates to tackle bacterial infections and tissue inflammation. However, these peptides …

With the rapid rise in the incidence of multidrug resistant infections, there is substantial
interest in host defense peptides as templates for production of new antimicrobial …

Innate defense regulators (IDRs) are synthetic immunomodulatory versions of natural host
defense peptides (HDP). IDRs mediate protection against bacterial challenge in the …

Non-natural amino acids can be incorporated into synthetic host defense peptides (HDPs) to
modulate their susceptibility to proteolytic degradation. However, the impact of non-natural …