microRNAs as pharmacological targets in cancer

A Soriano, L Jubierre, A Almazan-Moga, C Molist… - Pharmacological …, 2013 - Elsevier
The survival rate of cancer patients has increased considerably in the last 20 years owing to
significant efforts made in prevention, early detection protocols, combined chemotherapy …

Exploiting the therapeutic potential of microRNAs in human cancer

WCS Cho - Expert opinion on therapeutic targets, 2012 - Taylor & Francis
Dysregulation of microRNAs (miRNAs) has been widely shown to be associated with the
development and progression of cancer. Recent studies discovered a handful of miRNAs …

MicroRNAs as therapeutic targets and their potential applications in cancer therapy

WCS Cho - Expert opinion on therapeutic targets, 2012 - Taylor & Francis
Introduction: The results of cancer-associated miRNA research have yielded surprising
insights into the pathogenesis of a range of different cancers. Many of the dysregulated …

MicroRNAs as new therapeutic targets and tools in cancer

P Gandellini, V Profumo, M Folini… - Expert opinion on …, 2011 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that
negatively regulate gene expression at the post-transcriptional level. Several studies have …

microRNAs as cancer therapeutics: A step closer to clinical application

TC Ivkovic, G Voss, H Cornella, Y Ceder - Cancer letters, 2017 - Elsevier
During the last decades, basic and translational research has enabled great improvements
in the clinical management of cancer. However, scarcity of complete remission and many …

Developing therapeutic microRNAs for cancer

AG Bader, D Brown, J Stoudemire, P Lammers - Gene therapy, 2011 - nature.com
Despite substantial progress in understanding the cancer-signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …

Targeting microRNAs in cancer: rationale, strategies and challenges

R Garzon, G Marcucci, CM Croce - Nature reviews Drug discovery, 2010 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …

Targeting microRNAs in cancer gene therapy

W Ji, B Sun, C Su - Genes, 2017 - mdpi.com
MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in
regulating gene expression by targeting multiple molecules. Early studies have shown that …

Advances in the discovery of microRNA-based anticancer therapeutics: latest tools and developments

KKW To, W Fong, CWS Tong, M Wu… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that repress the
expression of their target genes by reducing mRNA stability and/or inhibiting translation …

Shielding the messenger (RNA): microRNA-based anticancer therapies

E Sotillo, A Thomas-Tikhonenko - Pharmacology & therapeutics, 2011 - Elsevier
It has been a decade since scientists realized that microRNAs (miRNAs) are not an oddity
invented by worms to regulate gene expression at post-transcriptional levels. Rather, many …