Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

Y Wan, MH Tang, XC Chen, LJ Chen… - Brazilian Journal of …, 2014 - SciELO Brasil
Immune response plays an important role in the development of hepatic fibrosis. In the
present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis …

The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

ES Lee, HE Lee, JY Shin, S Yoon… - Journal of pharmacy …, 2003 - Wiley Online Library
Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

Beneficial effect of quercetin on cholestatic liver injury

SY Lin, YY Wang, WY Chen, YH Chuang… - The Journal of …, 2014 - Elsevier
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury,
cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress …

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …

[HTML][HTML] Protective/preventive effects of quercetin against cyclophosphamide-induced hepatic inflammation, apoptosis and fibrosis in rats

S Turedi - Hepatology Forum, 2023 - ncbi.nlm.nih.gov
Materials and Methods Thirty female rats were divided into five groups–control, quercetin
(Q), CYC, Q+ CYC, and CYC+ Q. At the end of the study, the liver tissues were removed and …

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

R Wang, H Zhang, Y Wang, F Song, Y Yuan - International …, 2017 - Elsevier
Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …

Quercetin reverses experimental cirrhosis by immunomodulation of the proinflammatory and profibrotic processes

S Casas‐Grajales, LF Vázquez‐Flores… - Fundamental & …, 2017 - Wiley Online Library
The ability of quercetin to reverse an established cirrhosis has not yet been investigated.
Therefore, the aim of this study was to examine the efficacy of this flavonoid in reversing …

[HTML][HTML] Quercetin alleviates liver fibrosis via regulating glycolysis of liver sinusoidal endothelial cells and neutrophil infiltration

X Chen, Y Wang, J Wan, X Dou… - Biomolecules and …, 2024 - pmc.ncbi.nlm.nih.gov
Liver fibrosis, a common characteristic in various chronic liver diseases, is largely influenced
by glycolysis. Quercetin (QE), a natural flavonoid known to regulate glycolysis, was studied …

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

L Wu, Q Zhang, W Mo, J Feng, S Li, J Li, T Liu, S Xu… - Scientific reports, 2017 - nature.com
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

The construction of preclinical evidence for the treatment of liver fibrosis with quercetin: A systematic review and meta‐analysis

X Guo, Y Li, W Wang, L Wang, S Hu… - Phytotherapy …, 2022 - Wiley Online Library
Abstract Quercetin (3, 3′, 4′, 5, 7‐pentahydroxyflavone), a flavonoid, is widely found in
fruits and vegetables and exerts broad‐spectrum pharmacological effects in the liver. Many …