The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway

I Ayed-Boussema, C Bouaziz, K Rjiba, K Valenti… - Toxicology in vitro, 2008 - Elsevier
Zearalenone (Zen) is a fusarial mycotoxin commonly found in several food commodities
worldwide. It is frequently implicated in reproductive disorders and exerts several genotoxic …

Sequential events of apoptosis induced by zearalenone in cultured hepatocarcinoma cells

AC Gazzah, E El Golli Bennour, C Bouaziz, S Abid… - Mycotoxin …, 2010 - Springer
Zearalenone (ZEA) is a fungal metabolite that can contaminate feed and foodstuffs and can
cause serious health problems for animals as well as for humans. The present investigation …

Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells

C Bouaziz, E El Golli, S Abid-Essefi, C Brenner… - Toxicology, 2008 - Elsevier
Mycotoxins, secondary metabolites produced by moulds, have been shown to cause diverse
toxic effects in animals and are also suspected of disease causation in humans. The present …

Mycotoxin zearalenone induces AIF-and ROS-mediated cell death through p53-and MAPK-dependent signaling pathways in RAW264. 7 macrophages

JY Yu, ZH Zheng, YO Son, X Shi, YO Jang, JC Lee - Toxicology in Vitro, 2011 - Elsevier
Zearalenone (ZEN) is commonly found in many food commodities and is known to cause
reproductive disorders and genotoxic effects. However, the mode of ZEN-induced cell death …

Zearalenone induced toxicity in SHSY-5Y cells: the role of oxidative stress evidenced by N-acetyl cysteine

M Venkataramana, SC Nayaka, T Anand… - Food and chemical …, 2014 - Elsevier
Zearalenone (ZEN) is a mycotoxin from Fusarium species commonly found in many food
commodities and are known to cause reproductive disorders, genotoxic and …

Zearalenone induces apoptosis and autophagy in a spermatogonia cell line

R Lee, DW Kim, WY Lee, HJ Park - Toxins, 2022 - mdpi.com
Zearalenone (ZEN), a widely known mycotoxin, is mainly produced by various Fusarium
species, and it is a potent estrogenic metabolite that affects reproductive health in livestock …

Mycotoxin zearalenone induces apoptosis in mouse Leydig cells via an endoplasmic reticulum stress-dependent signalling pathway

P Lin, F Chen, J Sun, J Zhou, X Wang, N Wang… - Reproductive …, 2015 - Elsevier
Zearalenone (ZEN) is a Fusarium mycotoxin that causes several reproductive disorders and
genotoxic effects. This study demonstrated the involvement of endoplasmic reticulum (ER) …

The role of oxidative stress in zearalenone-mediated toxicity in Hep G2 cells: Oxidative DNA damage, gluthatione depletion and stress proteins induction

W Hassen, I Ayed-Boussema, AA Oscoz, ADC Lopez… - Toxicology, 2007 - Elsevier
Zearalenone (ZEN) is a fusarial mycotoxin with several adverse effects in laboratory and
domestic animals including mainly estrogenicity. While most ZEN toxic effects have been …

[HTML][HTML] Crocin and Quercetin protect HCT116 and HEK293 cells from Zearalenone-induced apoptosis by reducing endoplasmic reticulum stress

IB Salem, A Prola, M Boussabbeh, A Guilbert… - Cell Stress and …, 2015 - Elsevier
Mycotoxins are considered to be significant contaminants of food and animal feed.
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by several species of …

Zearalenone induces endoplasmic reticulum stress and modulates the expression of phase I/II enzymes in human liver cells

JE Yoon, KY Lee, JS Seok, WN Cheng, HC Kwon… - Toxins, 2019 - mdpi.com
Zearalenone (ZEN) is a mycotoxin produced by Fusarium species; however, its mechanisms
of action in human livers have not been fully elucidated. Thus, we investigated the toxic …