Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …

Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of …

Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to
an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is …

Sickle cell disease is a systemic disorder that is caused by a mutation (Glu6Val) in the gene
that encodes β globin. The sickle hemoglobin molecule (HbS) is a tetramer of two α-globin …

Sickle cell disease has been very well characterized as a single amino acid molecular
disorder of hemoglobin leading to its pathological polymerization, with resulting red cell …

Sickle cell disease (SCD) is characterized by a point mutation that replaces adenine with
thymidine in the sixth codon of the β-globin gene, a unique morphological abnormality of red …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide, affecting almost 400,000 newborns globally each year. It is characterized by …

In sickle cell disease, a single base pair substitution in the gene encoding the β-globin chain
of the haemoglobin molecule gives rise to a surprisingly broad spectrum of …

Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin
gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS) …