We determined the folding of chromosomes in interphase nuclei by measuring the distance
between points on the same chromosome. Over 25,000 measurements were made in G0/G1 …

The large-scale structure of chromatin corresponding to G-and R-bands in human G 0/G 1
interphase nuclei was compared. Fluorescence in situ hybridization (FISH) was used to …

Each level of DNA folding in cells corresponds to a distinct chromatin structure. The basic
chromatin units, nucleosomes, are arranged into solenoids which form chromatin loops. To …

Fluorescence in situ hybridization data on distances between defined genomic sequences
are used to construct a quantitative model for the overall geometric structure of a human …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

We have used light microscopy and serial thin-section electron microscopy to visualize
intermediates of chromosome decondensation during G1 progression in synchronized CHO …

The overall geometry of chromosomes in mammalian cells during interphase is analyzed.
On scales larger than approximately 10 (5) bp, a chromosome is modeled as a Gaussian …

The folding of chromatin in interphase cell nuclei was studied by fluorescent in situ
hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences …

The DNA in nuclei and chromosomes is highly organized on several different levels, from
winding of the helix around histones to the clustering of hundreds of kilobase pairs into the …

The last years have witnessed rapid progress in our understanding of chromatin structure at
the nucleosome or beads-on-a-string level (Elgin and Weintraub 1975; Kornberg 1977) …