The prothrombotic nature of sickle cell disease (SCD) is evidenced by the chronically
elevated levels of almost all coagulation activation biomarkers, and an increased incidence …

Essentials• Sickle cell disease is increasingly being recognized as a chronic
hypercoagulable state.• Thrombin generation is elevated in the whole blood, but not the …

Sickle cell disease (SCD) is considered to be a hypercoagulable state with chronic
activation of coagulation and an increased incidence of thrombotic events. However, there is …

Abstract Abstract 2587 Poster Board II-563 Background: SCD is considered to be a
hypercoagulable state. Because of the great complexity of the hemostatic system it has not …

It has been well-described that sickle cell disease (SCD) due to HbSS or HbSC is
associated with systemic activation of coagulation. A single study has reported a similar …

Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin
generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic …

Recent epidemiologic data suggest that sickle cell trait (Hb AS; AS) is a risk factor for venous
thromboembolism. We conducted an exploratory study of healthy subjects with AS under …

In the present study we examined if, among other mechanisms, the abnormal exposure of
phosphatidylserine at the surface of sickle red blood cells (RBCs) contributes to the …

Homozygous sickle cell disease (HbSS; SCD) is associated with vaso-occlusive
manifestations of varying severity [1]. Pain crises are generally believed to result from …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …