Background Deep brain stimulation (DBS) has demonstrated potential in mitigating
Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its …

Background Before the deposition of amyloid-beta plaques and the onset of learning
memory deficits, patients with Alzheimer's disease (AD) experience olfactory dysfunction …

Background Alzheimer's disease (AD) is a progressive degenerative disorder that currently
remains extremely disabling. Recent work has shown that deep brain stimulation (DBS) has …

The sense of smell has been shown to deteriorate in patients with some neurodegenerative
disorders. In Parkinson's disease (PD) and Alzheimer's disease (AD), decreased ability to …

Neural synchrony in brain circuits is the mainstay of cognition, including memory processes.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that disrupts neural …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline. Deep brain stimulation (DBS) has been used to treat a variety of brain …

An early symptom of Alzheimer's disease (AD) is an impaired sense of smell, for which the
molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived …

The olfactory dysfunction can signal and act as a potential biomarker of preclinical AD.
However, the precise regulatory mechanism of olfactory function on the neural pathogenesis …

The unique vulnerability of the olfactory system to Alzheimer's disease (AD) provides a
quintessential translational tool for understanding mechanisms of synaptic dysfunction and …

Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity.
Olfactory dysfunction manifests early in several neurodegenerative disorders including …