The field of Alzheimer disease (AD) has a nosologic problem: The diagnostic label
“Alzheimer disease” has several distinctive meanings. The term probable AD was …

Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

Publisher Summary This chapter describes that Alzheimer's disease (AD) is the most
prevalent form of dementia in individuals age 65 and older. The pathological substrate of the …

Objective To determine the prevalence of preclinical Alzheimer disease (AD) according to
current classification systems by examining CSF from a representative general population …

As modern society ages rapidly, the number of people with dementia is sharply increasing.
Direct medical costs and indirect social costs for dementia patients are also increasing …

Importance Since 2018, a movement has emerged to define Alzheimer disease (AD) as a
purely biological entity based on biomarker findings. The recent revision of the Alzheimer's …

Despite recognition that Alzheimer's disease (AD) is a polygenic and heterogeneous
dementing neurodegenerative disorder, there is continued merit in defining the AD …

The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Objective: To describe the experience of a research clinic diagnosing AD during the last two
decades, with special emphasis on patients who meet the National Institute of Neurological …

In 1907, when Alois Alzheimer first described the clinical and pathologic findings in the case
of 54-year-old Auguste D., her severe and progressive dementia had been grossly obvious …