The effect of different processing factors on tissue valve calcification were studied in the
subdermal rat model. Factors evaluated, were the influence of tissue ischaemia (4 degrees …

The lifetime of bioprosthetic heart valves is limited by primary tissue failure and calcification
of the valve leaflets. There are indications that synthetic elastomeric materials may also be …

Experiments were performed to better understand the relationship between glutaraldehyde
and calcification of bioprosthetic heart valves, using both the cusps and the wall of porcine …

Recent epidemiologic, histologic, and molecular studies suggest that the pathogenesis of
degenerative disease of the native aortic valve resembles that of atherosclerosis. 1-3 The …

To study the process of calcification in bioprostheses, 108 glutaraldehyde-treated porcine
aortic valve leaflets were implanted subcutaneously in rabbits and removed 1 day to 6 …

The principal cause of the clinical failure of bioprosthetic heart valves fabricated from
glutaraldehyde‐pretreated porcine aortic valves is calcification. Other prostheses composed …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

Previous work in our laboratory has demonstrated a simple, dynamic in vitro calcification
method for studying bovine pericardial heart valves. The calcification produced closely …

Calcification of bioprosthetic heart valves: a perspective on models. - Abstract - Europe PMC
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To determine the incidence and extent of calcification of implanted glutaraldehyde-treated
porcine prosthetic heart valves, 82 valves explanted from 73 patients were examined for …