To allow for sufficient time to repair DNA double-stranded breaks (DSBs), eukaryotic cells
activate the DNA damage checkpoint. In budding yeast, Rad53 (mammalian Chk2) …

Mammalian ATR and ATM checkpoint kinases modulate chromatin structures near DNA
breaks by phosphorylating a serine residue in the carboxy-terminal tail SQE motif of histone …

Double-strand breaks (DSB) in yeast lead to the formation of repair foci and induce a
checkpoint response that requires both the ATR-related kinase Mec1 and its target, Rad53 …

To counteract the continuous exposure of cells to agents that damage DNA, cells have
evolved complex regulatory networks called checkpoints to sense DNA damage and …

Oligomeric assembly of Brca1 C-terminal (BRCT) domain-containing mediator proteins
occurs at sites of DNA damage. However, the functional significance and regulation of such …

One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine
phosphorylation of the histone variant H2AX at the carboxy-terminal SQE motif to create …

One of the earliest events in the signal transduction cascade that initiates a DNA damage
checkpoint is the phosphorylation on serine 139 of histone H2AX (γH2AX) at DNA double …

DNA damage signaling and repair take place in a chromatin context. Consequently,
chromatin-modifying enzymes, including adenosine triphosphate–dependent chromatin …

The evolutionarily conserved yeast checkpoint protein kinase Rad53 regulates cell cycle
progression, transcription, and DNA repair in response to DNA damage. To uncover …

The strength of the DNA damage checkpoint critically influences cell fate, yet the
mechanisms behind the fine tuning of checkpoint strength during the DNA damage …