The lifetime of bioprosthetic heart valves is limited by primary tissue failure and calcification
of the valve leaflets. There are indications that synthetic elastomeric materials may also be …

Calcification of bioprosthetic heart valves: a perspective on models. - Abstract - Europe PMC
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Previous work in our laboratory has demonstrated a simple, dynamic in vitro calcification
method for studying bovine pericardial heart valves. The calcification produced closely …

Methods Four bovine pericardial and two porcine mitral valves (Baxter) with a tissue annulus
diameter (TAD) of 29 mm (one 27 mm) were investigated in parallel under identical test …

Both in vivo and in vitro models have been developed to study the initiation and progression
of dystrophic calcification of bioprosthetic heart valves. Circulatory in vivo models have …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

The most predictable cause of failure of a biological prosthetic heart valve is calcification.
The deposition process appears to be related both to the biomaterial composition and to the …

To study the process of calcification in bioprostheses, 108 glutaraldehyde-treated porcine
aortic valve leaflets were implanted subcutaneously in rabbits and removed 1 day to 6 …

The effect of different processing factors on tissue valve calcification were studied in the
subdermal rat model. Factors evaluated, were the influence of tissue ischaemia (4 degrees …

To determine the incidence and extent of calcification of implanted glutaraldehyde-treated
porcine prosthetic heart valves, 82 valves explanted from 73 patients were examined for …