Long‐term efficacy and safety of apremilast in psoriatic arthritis: Focus on skin manifestations and special populations

A Balato, E Campione, T Cirillo, G Malara… - Dermatologic …, 2020 - Wiley Online Library
Few real‐life studies evaluated long‐term apremilast therapy in the variable spectrum of
clinical‐anamnestic features which can be found in psoriatic arthritis (PsA) patients. This real …

Longterm (52-week) results of a phase III randomized, controlled trial of apremilast in patients with psoriatic arthritis

A Kavanaugh, PJ Mease, JJ Gomez-Reino… - The Journal of …, 2015 - jrheum.org
Objective. To evaluate the efficacy and safety of apremilast, an oral phosphodiesterase 4
inhibitor, over 52 weeks in patients with active psoriatic arthritis (PsA) despite prior …

Retrospective evaluation of patient profiling and effectiveness of apremilast in an Italian multicentric cohort of psoriatic arthritis patients.

EG Favalli, F Conti, C Selmi, F Iannone… - Clinical and …, 2019 - europepmc.org
Objectives We aimed to evaluate the baseline characteristics, the reasons for prescription,
and the effectiveness/safety profile of real-life apremilast for the treatment of psoriatic arthritis …

Oral apremilast in the treatment of active psoriatic arthritis: results of a multicenter, randomized, double‐blind, placebo‐controlled study

G Schett, J Wollenhaupt, K Papp, R Joos… - Arthritis & …, 2012 - Wiley Online Library
Objective To evaluate the efficacy and safety of apremilast, a novel, orally available small
molecule that specifically targets phosphodiesterase 4, in the treatment of active psoriatic …

A phase III, randomized, controlled trial of apremilast in patients with psoriatic arthritis: results of the PALACE 2 trial

M Cutolo, GE Myerson, RM Fleischmann… - The Journal of …, 2016 - jrheum.org
Objective. Apremilast, an oral phosphodiesterase 4 inhibitor, downregulates intracellular
inflammatory mediator synthesis by elevating cyclic adenosine monophosphate levels. The …

New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast

AC Palfreeman, KE McNamee… - … design, development and …, 2013 - Taylor & Francis
Psoriasis is a chronic inflammatory skin disease, most commonly resulting in the occurrence
of red and silver scaly plaques. About 30% of psoriasis sufferers develop psoriatic arthritis …

Long‐Term Safety and Tolerability of Apremilast Versus Placebo in Psoriatic Arthritis: A Pooled Safety Analysis of Three Phase III, Randomized, Controlled Trials

PJ Mease, DD Gladman… - ACR open …, 2020 - Wiley Online Library
Objective Psoriatic arthritis (PsA) requires long‐term treatment, yet safety concerns and
monitoring requirements make maintenance a challenge. This analysis of pooled Psoriatic …

Long-term experience with apremilast in patients with psoriatic arthritis: 5-year results from a PALACE 1–3 pooled analysis

A Kavanaugh, DD Gladman, CJ Edwards… - Arthritis research & …, 2019 - Springer
Background The efficacy and safety of apremilast were assessed in patients with psoriatic
arthritis (PsA) in three phase III clinical trials with similar designs (PALACE 1, 2, and 3) …

Apremilast for the treatment of psoriatic arthritis

A Souto, JJ Gómez-Reino - Expert review of clinical immunology, 2015 - Taylor & Francis
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints that occurs in patients
with psoriasis. The spectrum of PsA includes arthritis, dactylitis, enthesitis, axial involvement …

Psoriatic patients with a history of cancer: A real‐life experience with Apremilast treatment for 104 weeks

N Bernardini, N Skroza, A Marchesiello… - Dermatologic …, 2022 - Wiley Online Library
Psoriasis is a multifactorial, chronic, auto‐inflammatory disease, with a worldwide
prevalence of around 2%, subtended by robust genetic predisposition and autoimmune …