OBJECTIVE Caspase-1 plays an important functional role mediating neuronal cell death
and dysfunction after experimental traumatic brain injury (TBI) in mice. Minocycline, a …

Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Minocycline, a clinically used tetracycline for over 40 years, crosses the blood–brain barrier
and prevents caspase up‐regulation. It reduces apoptosis in mouse models of Huntington's …

Minocycline ameliorates deficits in models of acute and chronic neurological diseases, but
many publications do not replicate these results. We tested the hypothesis that a key factor …

Traumatic brain injury (TBI) causes a wide spectrum of consequences, such as microglial
activation, cerebral inflammation, and focal and diffuse brain injury, as well as functional …

We examined the effects of minocycline, an anti-inflammatory drug, on functional recovery
following spinal cord injury (SCI). Rats received a mild, weight-drop contusion injury to the …

Background Minocycline, a second-generation tetracycline with anti-inflammatory and anti-
apoptotic properties, has been shown to promote therapeutic benefits in experimental …

To review the neuroprotective effects of minocycline in focal cerebral ischemia in animal
models. By searching in the databases of PubMed, ScienceDirect, and Scopus, and …

Hypoxic‐ischemic brain injury in the perinatal period is a major cause of morbidity and
mortality. Presently, there are no proven effective therapies with which to safeguard the …

This study was initiated due to an NIH “Facilities of Research—Spinal Cord Injury” contract
to support independent replication of published studies that could be considered for a …