An amino acid exchange (P209L) in the HSPB8 binding site of the human co-chaperone
BAG3 gives rise to severe childhood cardiomyopathy. To phenocopy the disease in mice …

Bcl-2-associated athanogene 3 (BAG3) is a cochaperone protein and a central player of the
cellular protein quality control system. BAG3 is prominently expressed in the heart and plays …

The most common cause of dilated cardiomyopathy and heart failure (HF) is ischemic heart
disease; however, in a third of all patients the cause remains undefined and patients are …

Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular
dilatation and systolic dysfunction. Familial DCM is reportedly caused by mutations in more …

Dear Editor, Bcl-2-associated athanogene 3 (BAG3) protein belongs to the family of co-
chaperones that interact with the ATPase domain of the heat shock protein HSP70 through …

BAG3 is a cellular protein that is expressed predominantly in skeletal and cardiac muscle
but can also be found in the brain and in the peripheral nervous system. BAG3 functions in …

Abstract Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein
that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to …

Molecular chaperones regulate quality control in the human proteome, pathways that have
been implicated in many diseases, including heart failure. Mutations in the BAG3 gene …

Defective protein quality control (PQC) systems are implicated in multiple diseases.
Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant …

The Bcl2-associated anthanogene (BAG) 3 protein is a member of the BAG family of
cochaperones, which supports multiple critical cellular processes, including critical structural …