Does constant infusion of gonadotropin-releasing hormone agonist lead to greater suppression of gonadal function in man than its intermittent administration?

S Bhasin, B Steiner, R Swerdloff - Fertility and sterility, 1985 - Elsevier
Constant infusion of gonadotropin-releasing hormone agonist (GnRH-A) in the rhesus
monkey leads to far greater suppression of spermatogenesis than its intermittent …

Hormonal effects of gonadotropin-releasing hormone (GnRH) agonist in men: effects of long term treatment with GnRH agonist infusion and androgen

S Bhasin, QX Yuan, BS Steiner… - The Journal of Clinical …, 1987 - academic.oup.com
Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …

Influence of continuous gonadotropin-releasing hormone (GnRH) agonist treatment on luteinizing hormone and testosterone secretion, the response to GnRH, and the …

DR MANN, KG GOULD… - The Journal of Clinical …, 1984 - academic.oup.com
Five adult male rhesus monkeys were continuously infused for 56 dayswith 25 μg/day of
GnRH agonist (Wy-40972; Ag) using an implanted osmotic pump. Bioassayable serum …

Influence of simultaneous gonadotropin-releasing hormone agonist and testosterone treatment on spermatogenesis and potential fertilizing capacity in male monkeys

DR MANN, KG GOULD, MM SMITH… - The Journal of …, 1987 - academic.oup.com
We examined the effect of continuous sc infusion of a GnRH agonist (Ag) and testosterone
(T) supplementation on spermatogenesis and the potential fertilizing capacity of sperm in 15 …

Hormonal effects of gonadotropin-releasing hormone (GnRH) agonist in the human male. III. Effects of long term combined treatment with GnRH agonist and androgen

S Bhasin, D Heber, BS Steiner… - The Journal of …, 1985 - academic.oup.com
Chronic treatment with agonist analogs of GnRH results in reversible oligospermia i man,
but leads to impotence and decreased libido due to a concomitant fall in serum testosterone …

Effect of continuous infusion of a low dose of GnRH antagonist on serum LH and testosterone concentrations, spermatogenesis and semen quality in the rhesus …

DR Mann, DC Collins, MM Smith, KG Gould - Reproduction, 1987 - rep.bioscientifica.com
Treatment of 4 adult male rhesus monkeys for 8–12 months with 100–400 μg of a GnRH
antagonist/day by means of using osmotic minipumps led to suppressed serum …

Acute and chronic effects of a gonadotrophin-releasing hormone antagonist on pituitary and testicular function in monkeys

F Bint Akhtar, GF Weinbauer… - Journal of …, 1985 - joe.bioscientifica.com
The effects of a potent gonadotrophin-releasing hormone (GnRH) antagonist,(N-Ac-dp-Cl-
Phe 1, 2, d-Trp 3, d-Arg 6, d-Ala 10)-GnRH (Org 30276), on pituitary and testicular function of …

Effect of a gonadotropin-releasing hormone agonist on luteinizing hormone and testosterone secretion and testicular histology in male rhesus monkeys

DR Mann, MM Smith, KG Gould, DC Collins - Fertility and sterility, 1985 - Elsevier
Three adult male rhesus monkeys were treated for 20 weeks with a gonadotropin-releasing
hormone (GnRH) agonist (Ag; Wy-40972; Wyeth Laboratories, Philadelphia, PA) using …

Testosterone Prevents Complete Suppression of Spermatogenesis in the Gonadotropin-Releasing Hormone Antagonist-Treated Nonhuman Primate (Macaco …

GF WEINBAUER, E GÖCKELER… - The Journal of Clinical …, 1988 - academic.oup.com
We studied the effects of administration of a GnRH antagonist combined with testosterone
(T) as an approach to male contraception as well as the role of intratesticular androgens in …

Hormonal effects of GnRH agonist in the human male: II. Testosterone enhances gonadotrophin suppression induced by GnRH agonist

S Bhasin, D Heber, B Steiner, M Peterson… - Clinical …, 1984 - Wiley Online Library
Superactive analogues of gonadotrophin releasing hormone and testosterone, when
administered together, synergistically inhibit gonadotrophin secretion and spermatogenesis …