A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket

AF Chai, EMM Bulloch, GL Evans, JS Lott… - … Section D: Biological …, 2015 - journals.iucr.org
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis. Access to iron in
host macrophages depends on iron-chelating siderophores called mycobactins and is …

A genetic locus required for iron acquisition in Mycobacterium tuberculosis

R Krithika, U Marathe, P Saxena… - Proceedings of the …, 2006 - National Acad Sciences
Mycobactins are a family of membrane-associated siderophores required for Mycobacterium
tuberculosis to adapt to its intracellular habitat. These lipophilic siderophores have been …

Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis

CA Madigan, TY Cheng, E Layre… - Proceedings of the …, 2012 - National Acad Sciences
To measure molecular changes underlying pathogen adaptation, we generated a
searchable dataset of more than 12,000 mass spectrometry events, corresponding to lipids …

Mechanistic analysis of Mycobacterium tuberculosis Rv1347c, a lysine Nε-acyltransferase involved in mycobactin biosynthesis

BA Frankel, JS Blanchard - Archives of biochemistry and biophysics, 2008 - Elsevier
Mycobactin acylation plays a crucial role in the ability of Mycobacterium tuberculosis to
acquire intracellular iron during infection. M. tuberculosis Rv1347c, the lysine Nε …

Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis

AJ Harrison, RJ Ramsay, EN Baker… - … Section F: Structural …, 2005 - journals.iucr.org
Mycobacterium tuberculosis, the causative agent of tuberculosis, depends on the secretion
of salicylate-based siderophores called mycobactins for the acquisition of extracellular iron …

Post-translational acetylation of MbtA modulates mycobacterial siderophore biosynthesis

O Vergnolle, H Xu, JAM Tufariello, L Favrot… - Journal of Biological …, 2016 - ASBMB
Iron is an essential element for life, but its soluble form is scarce in the environment and is
rarer in the human body. Mtb (Mycobacterium tuberculosis) produces two aryl-capped …

[PDF][PDF] Crystal structure of Mycobacterium tuberculosis FadB2 implicated in mycobacterial β-oxidation

JAG Cox, RC Taylor, AK Brown, S Attoe… - … Section D: Structural …, 2019 - journals.iucr.org
The intracellular pathogen Mycobacterium tuberculosis is the causative agent of
tuberculosis, which is a leading cause of mortality worldwide. The survival of M. tuberculosis …

Mutational and Phylogenetic Analyses of the Mycobacterial mbt Gene Cluster

SS Chavadi, KL Stirrett, UR Edupuganti… - Journal of …, 2011 - Am Soc Microbiol
The mycobactin siderophore system is present in many Mycobacterium species, including
M. tuberculosis and other clinically relevant mycobacteria. This siderophore system is …

The Crystal Structure of Rv1347c, a Putative Antibiotic Resistance Protein from Mycobacterium tuberculosis, Reveals a GCN5-related Fold and Suggests an …

GL Card, NA Peterson, CA Smith, B Rupp… - Journal of Biological …, 2005 - ASBMB
Mycobacterium tuberculosis, the cause of tuberculosis, is a devastating human pathogen.
The emergence of multidrug resistance in recent years has prompted a search for new drug …

Analyses of MbtB, MbtE, and MbtF suggest revisions to the mycobactin biosynthesis pathway in Mycobacterium tuberculosis

MD McMahon, JS Rush, MG Thomas - Journal of bacteriology, 2012 - Am Soc Microbiol
The production of mycobactin (MBT) by Mycobacterium tuberculosis is essential for this
bacterium to access iron when it is in an infected host. Due to this essential function, there is …