Computing optimal dynamic experiments for model calibration in predictive microbiology

E BALSA‐CANTO, AA Alonso… - Journal of Food Process …, 2008 - Wiley Online Library
The potential of mathematical models describing the microbial behavior during food
processing and storage largely depends on their predictive capabilities and, in this concern …

Introducing optimal experimental design in predictive modeling: A motivating example

KJ Versyck, K Bernaerts, AH Geeraerd… - International Journal of …, 1999 - Elsevier
Predictive microbiology emerges more and more as a rational quantitative framework for
predicting and understanding microbial evolution in food products. During the mathematical …

Comparing experimental design schemes in predictive food microbiology: Optimal parameter estimation of secondary models

L Mertens, E Van Derlinden, JF Van Impe - Journal of Food Engineering, 2012 - Elsevier
In predictive food microbiology, full factorial designs are still more the rule than the
exception, despite the huge experimental workload and cost related to this method. In this …

On the design of optimal dynamic experiments for parameter estimation of a Ratkowsky-type growth kinetics at suboptimal temperatures

K Bernaerts, KJ Versyck, JF Van Impe - International journal of food …, 2000 - Elsevier
It is generally known that accurate model building, ie, proper model structure selection and
reliable parameter estimation, constitutes an essential matter in the field of predictive …

The impact of experiment design on the parameter estimation of cardinal parameter models in predictive microbiology

E Van Derlinden, L Mertens, JF Van Impe - Food Control, 2013 - Elsevier
In predictive food microbiology, cardinal parameter models are often applied to describe the
effect of temperature, pH and/or water activity on the microbial growth rate. To identify the …

Optimal characterization of thermal microbial inactivation simulating non-isothermal processes

A Garre, G González-Tejedor, JL Peñalver-Soto… - Food Research …, 2018 - Elsevier
In this paper, optimal experimental design is applied for the characterization of the microbial
inactivation of Listeria monocytogenes under non-isothermal conditions, modelled by the …

Guidelines for the design of (optimal) isothermal inactivation experiments

JL Peñalver-Soto, A Garre, A Esnoz… - Food Research …, 2019 - Elsevier
Kinetic models are nowadays a basic tool to ensure food safety. Most models used in
predictive microbiology have model parameters, whose precision is crucial to provide …

Application of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kinetics

MM Gil, FA Miller, CLM Silva, TRS Brandão - Journal of Food Engineering, 2014 - Elsevier
The estimation of model parameters with high precision is of major importance in
mathematical predictions. If a mathematical model is properly chosen and if the primary …

Practical application of dynamic temperature profiles to estimate the parameters of the square root model

K Grijspeerdt, K De Reu - International journal of food microbiology, 2005 - Elsevier
Optimal experimental design for parameter estimation (OED/PE) is a promising method to
improve parameter estimation accuracy and minimise experimental effort in the field of …

Optimal experiment design for cardinal values estimation: guidelines for data collection

K Bernaerts, KPM Gysemans, TN Minh… - International Journal of …, 2005 - Elsevier
Optimal experiment design for parameter estimation (OED/PE) is an interesting technique for
modelling practices when aiming for maximum parameter estimation accuracy. Nowadays …