Integrative analysis of DNA methylation and gene expression to determine specific diagnostic biomarkers and prognostic biomarkers of breast cancer

M Zhang, Y Wang, Y Wang, L Jiang, X Li… - Frontiers in Cell and …, 2020 - frontiersin.org
Background: DNA methylation is a common event in the early development of various
tumors, including breast cancer (BRCA), which has been studies as potential tumor …

A seven‐DNA methylation signature as a novel prognostic biomarker in breast cancer

C Tao, R Luo, J Song, W Zhang… - Journal of Cellular …, 2020 - Wiley Online Library
Background Breast cancer (BC) is a common malignant tumor and its incidence and
mortality rates are ranked first among female cancers. So far, there has been no effective …

Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers

BP de Almeida, JD Apolónio, A Binnie… - BMC cancer, 2019 - Springer
Background Breast cancer is a highly heterogeneous disease resulting in diverse clinical
behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that …

Prognostic biomarker identification and tumor classification in breast cancer patients by methylation and transcriptome analysis

X Zhong, G Zhong - FEBS Open Bio, 2021 - Wiley Online Library
Breast cancer is one of the most common and heterogeneous malignancies. Although the
prognosis of breast cancer has improved with the development of early screening, the …

Deciphering the methylation landscape in breast cancer: diagnostic and prognostic biosignatures through automated machine learning

M Panagopoulou, M Karaglani, VG Manolopoulos… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BrCa) is characterized by aberrant DNA methylation. We
leveraged high-throughput methylation data from BrCa and normal breast tissues and …

Identification of differentially methylated genes as diagnostic and prognostic biomarkers of breast cancer

X Mao, Q Ye, G Zhang, J Jiang, H Zhao, Y Shao… - World journal of surgical …, 2021 - Springer
Background Aberrant DNA methylation is significantly associated with breast cancer.
Methods In this study, we aimed to determine novel methylation biomarkers using a …

A novel gene prognostic signature based on differential DNA methylation in breast cancer

C Zhu, S Zhang, D Liu, Q Wang, N Yang… - Frontiers in …, 2021 - frontiersin.org
Background: DNA methylation played essential roles in regulating gene expression. The
impact of DNA methylation status on the occurrence and development of cancers has been …

Genome-wide analysis of methylation-driven genes and identification of an eight-gene panel for prognosis prediction in breast cancer

Y Kuang, Y Wang, W Zhai, X Wang, B Zhang… - Frontiers in …, 2020 - frontiersin.org
Background Aberrant DNA methylation is a crucial epigenetic regulator that is closely
related to the occurrence and development of various cancers, including breast cancer (BC) …

Integrative analysis of DNA methylation and gene expression profiles identified potential breast cancer-specific diagnostic markers

X Liu, Y Peng, J Wang - Bioscience reports, 2020 - portlandpress.com
Breast cancer is a common malignant tumor among women whose prognosis is largely
determined by the period and accuracy of diagnosis. We here propose to identify a robust …

A seven-gene CpG-island methylation panel predicts breast cancer progression

Y Li, AA Melnikov, V Levenson, E Guerra, P Simeone… - BMC cancer, 2015 - Springer
Background DNA methylation regulates gene expression, through the inhibition/activation of
gene transcription of methylated/unmethylated genes. Hence, DNA methylation profiling can …