Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Heart valve disease is a significant cause of mortality worldwide. However, to date, a
nonthrombogenic, noncalcific prosthetic, which maintains normal valve mechanical …

Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Tissue-engineered heart valves have been proposed by physicians and scientists alike to
be the ultimate solution for treating valvular heart disease. Rather than replacing a diseased …

Potential applications of tissue engineering in regenerative medicine range from structural
tissues to organs with complex function. This review focuses on the engineering of heart …

The prevalence of valve disease is increasing worldwide. Given the need to reduce the
occurrence of complications experienced with mechanical and tissue valve replacements …

The current clinical solutions, including mechanical and bioprosthetic valves for valvular
heart diseases, are plagued by coagulation, calcification, nondurability, and the inability to …

Methods Fresh porcine aortic valve leaflets were treated with Triton X-100, sodium dodecyl
sulfate (SDS), sodium deoxycholate, MEGA 10, TnBP, CHAPS, and Tween 20, over a range …

Currently-used mechanical and biological heart valve prostheses have several
disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric …

Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is
now commonplace and generally enhances survival and quality of life. However, a …