The blocking action of 4-aminopyridine (4-AP) on the transient outward K+ current (I TO) in
isolated rat ventricular myocytes was studied using the whole-cell configuration of the patch …

The patch-clamp technique was used to study the relation between pinacidil and
intracellular ATP concentration [(ATP] i) on the activation of the outward K+ current in guinea …

The transient outward K+ current (Ito) was assessed in single rat ventricular myocytes with
the whole-cell patch-clamp technique. Extracellular application of the chemical phosphatase …

Block of the calcium-independent transient outward K+ current, I (to), by 4-aminopyridine (4-
AP) was studied in ferret right ventricular myocytes using the whole cell patch clamp …

Abstract The effects of disopyramide (1–30 μM) on the 4-aminopyridine sensitive transient
outward current (I to), on the rapid component of the delayed rectifier potassium current (I Kr) …

In rat ventricle, two Ca2+-insensitive components of K+ current have been distinguished
kinetically and pharmacologically, the transient, 4-aminopyridine (4-AP)-sensitive I to and …

The modulation of the transient outward K+ current (Ito) by divalent cations was studied in
enzymatically isolated rat ventricular myocytes with the whole cell patch-clamp technique. At …

The 1, 4-dihydropyridine (DHP) Ca2+ antagonists and agonists can inhibit a time-and
voltage-dependent, but intracellular Ca (2+)-independent transient outward K+ current (It), in …

Depolarization-activated outward K+ currents in isolated adult rat ventricular myocytes were
characterized using the whole-cell variation of the patch-clamp recording technique. During …

Imipramine is a tricyclic antidepressant drug that also exhibits antiarrhythmic effects and
whose clinical spectrum of activity is similar to that of quinidine. It has been previously …