It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

Increases in hydrogen peroxide can initiate protective responses to limit or repair oxidative
damage. However, hydrogen peroxide signals also fine-tune responses to growth factors …

Hydrogen peroxide (H2O2) is a well-documented component of living cells. It plays
important roles in host defense and oxidative biosynthetic reactions. In addition there is …

Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox
metabolism reactions and processes of the cells. H2O2 is recognized as one of the main …

Significance: Oxidants were once principally considered perpetrators of injury and disease.
However, this has become an antiquated view, with cumulative evidence showing that the …

A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …

Despite much recent interest in the biochemistry of reactive oxygen species, the
mechanisms by which hydrogen peroxide (H2O2) functions in mammalian cells remain …

Background Controlled generation and removal of hydrogen peroxide play important roles
in cellular redox homeostasis and signaling. We used a hydrogen peroxide biosensor …

Tissue injury and inflammation are associated with increased production of reactive oxygen
species (ROS), which have the ability to induce oxidative injury to various biomolecules …

Abstract Significance: Hydrogen peroxide (H 2 O 2) is generated in numerous biological
processes. It transmits cellular signals, contributes to oxidative folding of exported proteins …