Dependence of pituitary gonadotropin-releasing hormone (GnRH) receptors on GnRH secretion from the hypothalamus

DR Pieper, RR GAL, SR Regiani, JC Marshall - Endocrinology, 1982 - academic.oup.com
Recent studies in male rats have shown that the number of pituitary gonadotropin-releasing
hormone (GnRH) receptors is increased by castration and by injections of GnRH. This …

Pituitary gonadotropin-releasing hormone (GnRH) receptor responses to GnRH in hypothalamus-lesioned rats: inhibition of responses by hyperprolactinemia and …

DR PIEPER, RR GALA, MA SCHIFF… - …, 1984 - academic.oup.com
Increased hypothalamic GnRH secretion appears to influence positively the number of
pituitary GnRH receptors (GnRH-R). GnRH-R increase after castration in male rats, and this …

Hypothalamic regulation of pituitary gonadotropin-releasing hormone receptors: effects of gonadotropin-releasing hormone immunoneutralization

RN CLAYTON, RM POPKIN, HM FRASER - Endocrinology, 1982 - academic.oup.com
To further evaluate the role of GnRH in the regulation of pituitary gonadotropin-releasing
hormone receptors (GnRH-R) in male rats in vivo, endogenous GnRH was neutralized with …

Hypothalamic regulation of pituitary gonadotropin-releasing hormone receptors: effects of hypothalamic lesions and a gonadotropin-releasing hormone antagonist

RN CLAYTON, K Channabasavaiah… - …, 1982 - academic.oup.com
The role of the hypothalamus in maintenance of pituitary gonadotropin-releasing hormone
receptors (GnRH-R) and gonadotropin secretion was investigated by ablation of …

Gonadotropin-releasing hormone modulation of its own pituitary receptors: evidence for biphasic regulation

RN CLAYTON - Endocrinology, 1982 - academic.oup.com
To determine whether pituitary gonadotroph desensitization is a consequence of loss of
gonadotropin-releasing hormone (GnRH) receptors (GnRH-R), these were analyzed in …

Regulation of pituitary gonadotropin-releasing hormone receptors by gonadal hormones

RN CLAYTON, KJ CATT - Endocrinology, 1981 - academic.oup.com
The regulatory role of pituitary gonadotropinreleasing hormone (GnRH) receptors in the
control of gonadotropin secretion was investigated in male and female rats after castration …

Pituitary Gonadotropin-Releasing Hormone Receptor Regulation in the Hypogonadotrophic Hypogonadal (hpg) Mouse

LS Young, A Speight, HM Charlton, RN Clayton - Endocrinology, 1983 - academic.oup.com
Recent evidence indicates that endogenous GnRH is required for maintenance of its own
pituitary receptors (GnRH-R). We have measured GnRH-R in pituitaries of …

Pituitary gonadotropin-releasing hormone receptors. Effects of castration, steroid replacement, and the role of gonadotropin-releasing hormone in modulating …

MS Frager, DR Pieper, SA Tonetta… - The Journal of …, 1981 - Am Soc Clin Investig
To study the role of gonadotropin-releasing hormone (GnRH) receptors in the regulation of
gonadotropin secretion, we used D-125I-alanine6 des glycyl10 GnRH ethylamide (D-125I …

Gonadotrophin releasing hormone receptor regulation in relationship to gonadotrophin secretion

RN Clayton, A Detta, SI Naik, LS Young… - Journal of steroid …, 1985 - Elsevier
The relationship between pituitary GnRH receptors (GnRH-R) and LH responsiveness to
GnRH stimulation is not straightforward. In some circumstances, eg post-gonadectomy of …

Pituitary desensitization and the regulation of pituitary gonadotropin-releasing hormone (GnRH) receptors following chronic administration of a superactive GnRH …

D Heber, R Dodson, C Stoskopf, M Peterson… - Life Sciences, 1982 - Elsevier
We recently demonstrated that chronic daily administration of a superactive GnRH analog to
intact rats resulted in an initial stimulation of serum LH levels with a subsequent return of LH …