The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

A long strand of DNA is wrapped around the core histone and forms a nucleosome.
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …

The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional
regulation and other DNA-related biological processes. Here, we report the 11-angstrom …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Despite over 30years of work, the fundamental structure of eukaryotic chromatin remains
controversial. Here, we review the roots of this controversy in disparities between results …

Chromosome structure at the multi-nucleosomal level has remained ambiguous in spite of
its central role in epigenetic regulation and genome dynamics. Recent investigations of …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …

Eukaryotic genomes must be folded and compacted to fit within the restricted volume of the
nucleus. According to the current paradigm, strings of nucleosomes, termed 10nm chromatin …

How a long strand of genomic DNA is compacted into a mitotic chromosome remains one of
the basic questions in biology. The nucleosome fibre, in which DNA is wrapped around core …