Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Since calcification limits the durability of contemporary bioprosthetic heart valves,
antimineralization treatments are being widely investigated. Potential antimineralization …

Glutaraldehyde-preserved stent-mounted porcine aortic valve bioprostheses are widely
used in the surgical management of valvular heart disease [3, 13, 16, 17]. Since 1971 …

Bioprostheses, composed of chemically treated animal tissue and termed heterografts or
xenografts, are the most widely used type of substitute heart valve. Their major limitation is …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

Attempts to replace diseased human valves with prostheses began more than 30 yrs ago.
Heart valve prostheses can be broadly classified into mechanical prostheses (made out of …

The processes responsible for primary tissue failure of bioprostheses were illustrated.
Calcification is the major cause of failure of porcine bioprosthetic valves, usually with …

Despite distinct advantages over mechanical cardiac valve prostheses, the use of
bioprosthetic valves remains limited, due to poor long-term durability, primarily as a result of …

To study the process of calcification in bioprostheses, 108 glutaraldehyde-treated porcine
aortic valve leaflets were implanted subcutaneously in rabbits and removed 1 day to 6 …

Objective: Calcification is the most important cause of structural deterioration of
glutaraldehyde-fixed bioprosthetic valves. Devitalization of tissue favors calcium deposits in …