During the past 10 years or so, associated with the introduction of molecular biology
techniques to G protein coupled receptor (GPCR) research, outstanding progress has been …

Genetic variation in G protein-coupled receptors (GPCRs) results in the disruption of GPCR
function in a wide variety of human genetic diseases. In vitro strategies have been used to …

G-protein-coupled receptors (GPCRs), including 'orphan'GPCRs whose natural ligands are
unknown, comprise the largest membrane receptor superfamily and are the most commonly …

G protein-coupled receptors are under intense scrutiny as potential targets of drug research,
which stems mostly from the sheer size and diversity of this receptor family as well as the …

G protein-coupled receptors (GPCRs) represent a major class of proteins in the genome of
many species, including humans. In addition to the mapping of a number of human …

Single, bi-functional polypeptides consisting of a G-protein-coupled receptor (GPCR) linked
directly to a G protein α subunit have been employed for a number of years to study many …

The receptors that couple to G proteins (GPCR) and which span the cell membranes seven
times (7‐TM receptors) were the focus of a symposium in Stockholm 2006. The ensemble of …

G protein coupled receptors (GPCRs) are one of the largest human gene families, and are
targets for many important therapeutic drugs. Over the last few years, there has been a major …

Numerous genes encode G protein-coupled receptors (GPCRs)-a main molecular target for
drug therapy. Estimates indicate that the human genome contains approximately 600 GPCR …

This book is about the recent advances in the structural and functional characterization of
receptors that influence intracellular signalling events through interaction with intracellular …