In this review we describe major contributions of light and electron microscopic approaches
to the present understanding of functional nuclear architecture. The large gap of knowledge …

Ultrastructural cytochemistry has been, for many years now, a major tool for investigating
structure–function relationships in the cell nucleus. It has been essential in approaching the …

For many years, ultrastructural cytochemistry has been a major tool for investigating the
relationships between the structure and the functions of the cell nucleus. This article shortly …

In the age of “virtual reality,” the imperfect microscopic silhouettes of cells and organelles are
gradually being replaced by calligraphic computer drawings. In this context, textbooks and …

The nucleus contains a plethora of different dynamic structures involved in the regulation
and catalysis of nucleic acid metabolism and function. Over the past decades countless …

The nuclear architecture is considered an important contributor to genome function.
Although the fine structural features of the cell nucleus have been investigated extensively …

Advances in the specific fluorescent labeling of chromatin in fixed and living human cells in
combination with three-dimensional (3D) and 4D (space plus time) fluorescence microscopy …

Part II of this historical review on the progress of nuclear architecture studies points out why
the original hypothesis of chromosome territories from Carl Rabl and Theodor Boveri …

SCOPE AND INTRODUCTION Observation of the nucleus by electron microscopy has
yielded only limited information about its structure. This is mainly due to the absence of …

This electron microscopy review documents the in situ cytochemical localization of important
nuclear structures and relates this to the important nuclear functions of RNA transcription …